Intrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet -Cell Response to Hypoglycemia

نویسندگان

  • Huarong Zhou
  • Tao Zhang
  • Marika Bogdani
  • Elizabeth Oseid
  • Susan Parazzoli
  • Marie-Christine Vantyghem
  • Jamie Harmon
  • Michela Slucca
  • Paul Robertson
چکیده

OBJECTIVE—Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K group) of recipient Lewis rats previously rendered diabetic with streptozotocin (STZ).

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تاریخ انتشار 2008